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the main goal of this study is to understand the underlying neurobiological mechanisms of migraine and how stem cell therapy may be used as a therapeutic option to treat the headache condition. to accomplish this, we plan to induce migraine in rats and then perform stem cell therapy.
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the data on the ratio of the tubular epithelial cells with elevated expression of caspase-3 in the tubulointerstitial compartment as compared with that of normal control rats have shown that bmscs/keratinocytes co-transplantation will have higher effect in preventing injured kidney from fibrosis [42]. in our study, we also have shown that the transplanted bmscs differentiated into tubular cells and promoted the epithelial cell proliferation and attenuated the cell apoptosis after the keratinocytes transplantation, which played an important role in protecting the renal tubular cells from apoptosis after kidney injury. the transplantation of keratinocytes showed the role of repairing the damaged tubular cells by reducing the epithelial cell apoptosis and increasing the cell proliferation. but the effect was poor compared to bmsc transplantation, and it still had a protective effect on renal tubular cells under condition of the epithelial cell injury.] d8a7b2ff72
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